Journal: The AAPS Journal

Article Title: A Novel Beads-Based Dissolution Method for the In Vitro Evaluation of Extended Release HPMC Matrix Tablets and the Correlation with the In Vivo Data

doi: 10.1208/s12248-012-9422-x

Figure Lengend Snippet: Dissolution profiles of formulation A and B in the dissolution test T6. Measured dissolution points (A—diamonds, B—squares) and corresponding fitted Weibull functions (A—straight line, B—dotted line) are shown

Article Snippet: The procedure is as follows: The in vitro dissolution profiles of the formulations A and B were first fitted by the Weibull function using the OriginPro 8.0 software (© OriginLab Corporation): . where Fmax is maximum amount of dissolved drug, α and β parameters of the Weibull function, and t* time in vitro.

Techniques: Dissolution, Formulation

Journal: The AAPS Journal

Article Title: A Novel Beads-Based Dissolution Method for the In Vitro Evaluation of Extended Release HPMC Matrix Tablets and the Correlation with the In Vivo Data

doi: 10.1208/s12248-012-9422-x

Figure Lengend Snippet: The Estimated Parameters of the Weibull Function

Article Snippet: The procedure is as follows: The in vitro dissolution profiles of the formulations A and B were first fitted by the Weibull function using the OriginPro 8.0 software (© OriginLab Corporation): . where Fmax is maximum amount of dissolved drug, α and β parameters of the Weibull function, and t* time in vitro.

Techniques: Formulation

Journal: The Journal of Neuroscience

Article Title: Evoked Response Strength in Primary Auditory Cortex Predicts Performance in a Spectro-Spatial Discrimination Task in Rats

doi: 10.1523/JNEUROSCI.0041-18.2019

Figure Lengend Snippet: Individual animal task acquisition through consecutive shaping stages. A, Learning curves for sound localization without distractor. Rat1 and rat2 were trained on pure tones (8 kHz tone sequence; blue marker), whereas rats 9–12 were trained on white noise (same duration and amplitude parameters; black marker) and transitioned to pure tones once stable performance was reached. A cumulative Weibull function, fitted to the mean performance of consecutive behavioral sessions, shows each animal's dynamic learning phase (shaded green). B, Stable localization performance for white noise (wn), 4, 8, and 16 kHz (the pure tones used in the final spectra-spatial discrimination task). Mean performance and 95% binomial CIs are shown. C, Individual performance for rats 9–12 during the transition from the localization paradigm (no distractor) to the final target-distractor discrimination paradigm. Mean session performance is shown for 16 kHz localization without distractor (circles), with distractor at a 10–20 dB lower amplitude (squares), and finally with distractor amplitude-matched to the target (crosses; 60 dB SPL). Performance falls only when the full-volume distractor is introduced and quickly recovers. Behavioral sessions with the 8 kHz target were interspersed in the training (data not shown for clarity). Rat1 and rat2 were transitioned to the discrimination paradigm using a different pure tone frequency (24 kHz), thus data are not shown.

Article Snippet: A cumulative Weibull function was fitted to performance over consecutive sessions of the localization paradigm (no distractor) to produce learning curves ( A ), with the dynamic learning phase defined as the range between the first and ninth decile of the function, as previously described by Mayrhofer et al. (2013) .

Techniques: Sequencing, Marker